Umicore Expands Portfolio with Yale’s Hazari Precatalysts

2nd May 2019

Umicore Expands Portfolio with Yale’s Hazari Precatalysts

Umicore has licensed the Hazari precatalyst technology from Yale University to expand the cross-coupling catalyst portfolio of its business unit Precious Metals Chemistry.

Cross-coupling reactions are considered to be one of the most elegant and versatile synthetic methods for the production of agrochemicals, electronics, fine chemicals or pharmaceuticals. Compared to current systems, Hazari’s precatalysts can be activated rapidly and efficiently, thus significantly shortening reaction times and reducing catalyst loads. In addition, the reaction can be performed under milder conditions.

The air and moisture stable Hazari precatalysts are compatible with a wider variety of ancillary ligands – including N-heterocycle carbene, phosphine or even Buchwald type ligands – than many other commercially used precatalysts, resulting in an expanded substrate compatibility.

Moreover, an unligated dimeric version of the precatalyst, which can also be readily ligated, is available. Both of these features make the new precatalyst family effective unligated for ligand screening as well as ligated for commercial scale manufacturing.

The exclusive license agreement with Yale University enables Umicore to provide its customers access to a selection of Hazari’s precatalysts from research to commercial scale. The company’s expanded homogeneous catalysts portfolio and service offering now includes Buchwald precatalysts, Grubbs metathesis catalysts, and many more.

Photo: © Umicore
Umicore has licensed the Hazari precatalyst technology from Yale University to expand the cross-coupling catalyst portfolio of its business unit Precious Metals Chemistry.

For more information visit www.chemanager-online.com/en

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